Horse Endurance Supplements
WHAT IS AICAR?
AICAR also known as 5-Aminoimidazole-4-carboxamide riboside acts as an AMP-activated protein kinase agonist. AICAR (5-amino-4-imidazolecarboxamide riboside) is endogenously produced from an intermediate in the purine biosynthetic pathway. In human athletes, urine [AICAR] correlates with gender (males > females), athletic season (in competition > out of competition), and sport (weight lifting > soccer). Plasma AICAR was hypothesized to increase with exercise. An LC-MS-MS method was developed to quantify AICAR in plasma collected from race horses before and immediately after competition. Plasma AICAR was increased in the majority of horses after racing did not correlate with age, gender, or performance in this population. When administered intravenously, AICAR acutely decreased mean arterial blood pressure despite a compensatory increase in cardiac output and heart rate. Exercise-induced increases in AICAR may facilitate vasodilation. This work was supported by the Racing Medication and Testing Consortium, the PA Racing Commissions, the Pennsylvania Harness Horsemen Association, the Meadows Standardbred Owners Association, and the Pennsylvania Horsemen Benevolent and Protective Association.
HOW DOES IT WORK?
It stimulates glucose uptake and increases the activity of protein kinases in the skeletal muscle tissue and suppresses cell death. It significantly improves the performance in endurance-type exercise by converting fast-twitch muscle fibres to the slow-twitch type.
Significantly improvements in performance in endurance-type exercise, by converting fast-twitch muscle fibres to the more energy-efficient, fat-burning, slow-twitch type.
ADMINISTRATION AND DOSAGE
Available in boxes of 6 x 10 ml vials.
Acadenosine (AICAR) 50mg/ml (10ml Vial)
Refrigerated. Store between 3-8 degrees C
Keep out of reach from children.